EXOSC8

exosome component 8

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

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Antibodies (10)

Type

Primary (10)

Target

EXOSC8 (10)

Reactivity

Human (10)

Mouse (1)

Rat (1)

Application

IHC (3)

IHC-P (2)

WB (6)

Flo (1)

ELISA (6)

IF (1)

Peptide-ELISA (1)

Host

rabbit (9)

mouse (1)

Isotype

IgG (7)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (9)

Clone

1G5 (1)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (7)

Epitope

aa243-276 (1)

Publications

No (10)

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EXOSC8 Antibody LS-C665454

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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EXOSC8 Antibody (clone 1G5) LS-C133691

Antibody:

EXOSC8 Mouse anti-Human Monoclonal (1G5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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EXOSC8 Antibody (aa243-276) LS-C97265

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal (aa243-276) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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EXOSC8 Antibody LS-C803049

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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EXOSC8 Antibody LS-C397756

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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EXOSC8 Antibody (HRP) LS-C397757

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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EXOSC8 Antibody (Biotin) LS-C397759

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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EXOSC8 Antibody (FITC) LS-C397758

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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EXOSC8 Antibody LS-C766465

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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EXOSC8 Antibody LS-C668143

Antibody:

EXOSC8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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