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ETK / BMX

BMX non-receptor tyrosine kinase

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

Gene Name: BMX non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , BTK/TEC
Synonyms: BMX, PSCTK2, PSCTK3, ETK, NTK38, NTK38 tyrosine kinase, X-linked bone marrow kinase
Target Sequences: NM_001721 NP_001712.1 P51813

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Products
Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
ETK / BMX (9)
No (9)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (6)
Human (6)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (1)
ETK / BMX Protein - Purified recombinant protein BMX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
77.8 kDa
20 µg/$1,107
ETK / BMX Protein - Purified recombinant protein BMX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
77.8 kDa
20 µg/$1,107
ETK / BMX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
77.8 kDa
100 µg/$494
ETK / BMX Protein - Recombinant  BMX Non Receptor Tyrosine Kinase By SDS-PAGE
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E. coli
His-T7
30.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ETK / BMX Protein - Recombinant  BMX Non Receptor Tyrosine Kinase By SDS-PAGE
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E. coli
His-T7
30.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
ETK / BMX Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ETK / BMX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
77.8 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
77.8 kDa
20 µg/$150
ETK / BMX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
77.8 kDa
100 µg/$494
Viewing 1-9 of 9 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).