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May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Gene Name: | ESX homeobox 1 |
Synonyms: | ESX1, ESXR1, Homeobox protein ESX1, ESX1-related protein, ESX1L, ESX1R, ESX homeobox 1 |
Target Sequences: | Q8N693 Q8N693 |
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