Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation.
|Gene Name:||estrogen-related receptor beta|
|Family/Subfamily:||NHR , NR3 Steroid receptor|
|Synonyms:||ESRRB, DFNB35, ERRb, ERRbeta-2, ESRL2, Estrogen receptor-like 2, ERR-beta, ERRB2, ERRbeta, NR3B2, Nuclear receptor ERRB2, Orphan nuclear receptor, ERR beta-2, ERR2, Estrogen-related receptor 2, Estrogen-related receptor beta, Steroid hormone receptor ERR2|
|Target Sequences:||NM_004452 NP_004443.3 O95718|
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