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The endoribonuclease IRE2/ERN2 encodes the ER-to-nucleus signaling 2 protein, a human homolog of the yeast Ire1 gene product. In S. cerevisiae, as well as in human, this ER transmembrane IRE serine/threonine protein kinase monitors the status of unfolded proteins inside the ER lumen in response to stress.
Gene Name: | endoplasmic reticulum to nucleus signaling 2 |
Family/Subfamily: | Protein Kinase , IRE |
Synonyms: | ERN2, ER to nucleus signalling 2, HIRE2p, Inositol-requiring protein 2, IRE1-BETA, Inositol-requiring 1 beta, IRE1 beta, IRE2, IRE1b |
Target Sequences: | AB047079 BAB21297.1 Q76MJ5 |
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