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ERCC6L / FLJ20105
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
| Gene Name: | excision repair cross-complementing rodent repair deficiency, complementation group 6-like |
| Synonyms: | ERCC6L, PICH, RAD26L, FLJ20105, SNF2/RAD54 family protein, Tumor antigen BJ-HCC-15 |
| Target Sequences: | AK000112 NP_060139.2 Q2NKX8 |
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