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ERCC2 / XPD

excision repair cross-complementing rodent repair deficiency, complementation group 2

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Gene Name: excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms: ERCC2, COFS2, EM9, XPD, TFIIH p80, BTF2 p80, TTD, XPDC, CXPD, TFIIH 80 kDa subunit
Target Sequences: NM_000400 CAA36463.1 P18074

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ELISA Kits (1)
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ERCC2 / XPD (1)
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ERCC2 / XPD ELISA Kit
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Sandwich
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).