ERBB2 / HER2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

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Products

Proteins (41)

Type

Over-Expression Lysate (5)

Recombinant (36)

Target

ERBB2 / HER2 (41)

Application

Bind (4)

ELISA (4)

Func (4)

SDS-PAGE (8)

Publications

No (41)

Tag

6His, C-terminus (4)

6His, N-terminus (3)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (4)

Fc (1)

Fc, C-terminus (3)

Fc-AVI, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His,C-terminus (7)

His-GST (2)

His-GST, N-terminus (1)

His-T7 (1)

Human IgG Fc, C-terminus (2)

Myc-DDK (Flag) (6)

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Species

Human (28)

Mouse (5)

Rat (6)

Source

293T Cells (2)

Baculovirus (1)

CHO Cells (1)

E. coli (7)

HEK 293 Cells (18)

Human (1)

Human Cells (4)

Mammalian Cells (2)

Sf9 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (7)

Low Endotoxin Level

Low endotoxin level (21)

Biologically Active

Biologically active (4)

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Human ERBB2 / HER2 Protein (Recombinant 6His, N-terminus) (aa23-652) - LS-G20710

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

73.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ERBB2 / HER2 Protein (Recombinant 6His, N-terminus) (Thr23-Thr652) - LS-G26960

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

100 kDa

Price:

10 µg/$289; 50 µg/$360; 100 µg/$432

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Human ERBB2 / HER2 Protein (Recombinant GST) (Full Length) - LS-G28375

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

164.45 kDa

Price:

2 µg/$439

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Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr652) - LS-G47454

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.

Price:

100 µg/$488; 1 mg/$2,393

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Human ERBB2 / HER2 Protein (Over-Expression Lysate 6His, N-terminus) (Lys676-Val1255) - LS-G26741

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

70-80 kDa

Price:

100 µg/$298

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Human ERBB2 / HER2 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Thr652) - LS-G47281

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$1,991

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Human ERBB2 / HER2 Protein (Recombinant His, N-Terminal) (aa23-372) - LS-G24532

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

42.2 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human ERBB2 / HER2 Protein (Recombinant Fc, C-terminus) (Thr23-Thr652) - LS-G39502

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

96.5kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human ERBB2 / HER2 Protein (Recombinant His-GST) (aa376-578) - LS-G14420

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.4 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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ERBB2 / HER2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122163

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

134.7 kDa

Price:

100 µg/$710

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Rat ERBB2 / HER2 Protein (Recombinant Fc, C-terminus) (Met4-Thr656) - LS-G138224

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

97 kDa

Price:

100 µg/$721

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Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr652) - LS-G138120

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71 kDa

Price:

100 µg/$926; 1 mg/$4,701

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Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Pro489-Cys630) - LS-G47420

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa.

Price:

50 µg/$372; 500 µg/$1,285

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Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Cys195) - LS-G47426

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ERBB2 consists of 184 amino acids and predicts a molecular mass of 20.9 kDa.

Price:

50 µg/$348; 200 µg/$570

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Human ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr652) - LS-G47433

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, rh ErbB2 migrates as an approximately 100-110 kDa protein in SDS-PAGE under reducing conditions.

Price:

100 µg/$480; 1 mg/$2,324

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Human ERBB2 / HER2 Protein (Recombinant His-GST, N-terminus) (Lys676-Val1255) - LS-G47418

Source:

Baculovirus

Tag:

His-GST, N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human ErbB2 (676-1255)/GST chimera consists of 817 amino acids and predictes a molecular mass of 92 kDa. It migrates as an approximately 100 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$364

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Mouse ERBB2 / HER2 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Thr653) - LS-G47569

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse ERBB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 872 amino acids and has a calculated molecular mass of 96.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 120-130 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

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Mouse ERBB2 / HER2 Protein (Recombinant His,C-terminus) (Met1-Thr653) - LS-G47570

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse ERBB2 comprises 642 amino acids and has a calculated molecular mass of 71.1 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 100-110 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

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Human ERBB2 / HER2 Protein (Recombinant 6His, C-terminus) (Thr23-Thr652) - LS-G139148

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.1 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Rat ERBB2 / HER2 Protein (Recombinant) (Met4-Thr656) - LS-G140808

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.6 kDa

Price:

50 µg/$843

Select

Human ERBB2 / HER2 Protein (Recombinant DDK,C-terminus) - LS-G142337

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

138 kDa

Price:

20 µg/$677

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Human ERBB2 / HER2 Protein (Recombinant DDK,C-terminus) - LS-G142338

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

69 kDa

Price:

20 µg/$677

Select

Human ERBB2 / HER2 Protein (Recombinant DDK,C-terminus) - LS-G142313

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

64 kDa

Price:

20 µg/$677

Select

Human ERBB2 / HER2 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142195

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

72 kDa

Price:

20 µg/$1,107

Select

Human ERBB2 / HER2 Protein (Recombinant DDK,C-terminus) - LS-G145311

Source:

CHO Cells

Tag:

DDK,C-terminus

Molecular Weight:

137.7 kDa

Price:

50 µg/$1,111

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