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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EPM2A / Laforin

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.

Gene Name: epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Family/Subfamily: Protein Phosphatase , Laforin
Synonyms: EPM2A, EPM2, LAFPTPase, LDE, Lafora PTPase, MELF, Laforin, LD
Target Sequences: NM_005670 NP_005661.1 O95278

Filtered by: None
Target
EPM2A / Laforin (67)
Reactivity
Human (67)
Mouse (9)
Rat (14)
Bat (1)
Bovine (10)
Chimpanzee (6)
Dog (5)
Gibbon (6)
Monkey (9)
Orangutan (3)
Pig (9)
Rabbit (5)
Application
IHC (24)
IHC-P (6)
WB (56)
Flo (1)
DB (1)
ELISA (22)
ICC (21)
IF (7)
IP (2)
Peptide-ELISA (2)
RIA (1)
Host
rabbit (42)
mouse (23)
goat (2)
Isotype
IgG (31)
IgG1 (21)
IgG2a,k (1)
IgG2b (1)
Clonality
monoclonal mc (23)
polyclonal pc (44)
Clone
2323C3a (1)
4A12 (1)
K2A3 (1)
S84-37 (18)
Format
AP Conjugated (4)
APC Conjugated (4)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Azide-free (2)
Biotin Conjugated (8)
FITC Conjugated (7)
HRP Conjugated (6)
PE (1)
PE Conjugated (3)
PerCP Conjugated (1)
RPE Conjugated (1)
SA Conjugated (1)
Unconjugated (23)
Epitope
aa1-331 (18)
aa288-317 (8)
N-Terminus (7)
aa51-100 (4)
aa78-127 (4)
aa131-144 (1)
aa243-331 (1)
aa244-331 (1)
aa80-130 (1)
internal region (1)
Publications
No (67)
Showing 1-25 of 67 results

IHC-plus™ EPM2A / Laforin Antibody (aa131-144) LS-B6474
Goat Polyclonal to Human EPM2A / Laforin
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-EPM2A antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Anti-EPM2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.

IHC-plus™ EPM2A / Laforin Antibody LS-B8862
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $545.00
Anti-EPM2A / Laforin antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunocytochemistry of EPM2A in SW480 cells with EPM2A antibody at 2.5 ug/ml.

EPM2A / Laforin Antibody (aa288-317) LS-C327304
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
IHC, WB
Unconjugated
200µl  $590.00

EPM2A / Laforin Antibody (aa288-317, Biotin) LS-C225434
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
Biotin Conjugated
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317, FITC) LS-C225435
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
FITC Conjugated
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317, Azide-free, HRP) LS-C225437
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317, AP) LS-C225432
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
AP Conjugated
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317, APC) LS-C225433
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
APC Conjugated
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317, PE) LS-C225436
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
PE Conjugated
200µl  $740.00

EPM2A / Laforin Antibody (aa288-317) LS-C98183
Rabbit Polyclonal to Human EPM2A / Laforin
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with EPM2A antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of EPM2A (arrow) using rabbit polyclonal EPM2A Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EPM2A gene (Lane 2) (Origene Technologies).

EPM2A / Laforin Antibody (aa1-331) LS-C123477
Mouse Monoclonal (IgG2b) to Human EPM2A / Laforin
Human
ELISA, Flo, ICC, IF, IHC, IP, RIA, WB
Unconjugated
100µg  $650.00

EPM2A / Laforin Antibody LS-C677825
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
Immunofluorescent analysis of Hela cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IHC-plus™ EPM2A / Laforin Antibody (aa80-130) LS-B7949
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Bovine, Human
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-EPM2A / Laforin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Western blot of EPM2A in human heart lysate in the 1) absence and2) presence of immunizing peptide,3) mouse heart and 4) rat heart lysate using EPM2A / Laforin Antibody at 0.25 ug/ml, 0.5 ug/ml and 0.5 ug/ml, respectively.

EPM2A / Laforin Antibody LS-C334984
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.
Immunofluorescence analysis of HeLa cells.

EPM2A / Laforin Antibody LS-C668546
Rabbit Polyclonal to Human EPM2A / Laforin
Human
ICC, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunofluorescence Image
Western blot Image

EPM2A / Laforin Antibody (clone 2323C3a) LS-C184494
Mouse Monoclonal [clone 2323C3a] (IgG1) to Human EPM2A / Laforin
Human
DB, ICC, WB
Unconjugated
100µg  $560.00
Western blot of immunized recombinant protein using EPM2A antibody.

EPM2A / Laforin Antibody (aa244-331) LS-C375663
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, IHC-P
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human salivary gland using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.

EPM2A / Laforin Antibody (aa1-331, clone S84-37) LS-C209556
Mouse Monoclonal [clone S84-37] (IgG1) to Human EPM2A / Laforin
Human
ICC, WB
Unconjugated
100µg 1mg/ml  $365.00

EPM2A / Laforin Antibody (aa1-331, clone S84-37, Atto 390) LS-C229315
Mouse Monoclonal [clone S84-37] (IgG1) to Human EPM2A / Laforin
Human
ICC, WB
Atto 390 Conjugated
100µg  $395.00

EPM2A / Laforin Antibody (clone S84-37) LS-C760264
Mouse Monoclonal [clone S84-37] (IgG1) to Human EPM2A / Laforin
Human
IF, WB
Unconjugated
100µg  $425.00
Detection of Laforin in nueroblastoma cell line SK-N-BE with Laforin Monoclonal Antibody at 10ug/ml: DAPI (blue) nuclear stain, Texas Red F actin stain, ATTO 488 (green) Laforin stain.
Detection of Laforin in human hippocampus lysate with Laforin Monoclonal Antibody at 1ug/ml.

EPM2A / Laforin Antibody (N-Terminus) LS-C327298
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC
Unconjugated
200µl  $530.00

EPM2A / Laforin Antibody LS-C766388
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
IF, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

EPM2A / Laforin Antibody LS-C412660
Rabbit Polyclonal to Human EPM2A / Laforin
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00

EPM2A / Laforin Antibody (aa243-331, clone K2A3) LS-C93729
Mouse Monoclonal [clone K2A3] (IgG1) to Human EPM2A / Laforin
Human
ELISA, WB
Unconjugated
50µl 1mg/ml  $315.00; 100µl 1mg/ml  $345.00
Cell lysates of HeLa and 293T (20 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human EPM2A (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

EPM2A / Laforin Antibody (clone 4A12) LS-C139187
Mouse Monoclonal [clone 4A12] (IgG2a,k) to Human EPM2A / Laforin
Rat, Human
ELISA, WB
Unconjugated
100µg  $365.00
EPM2A monoclonal antibody (M01), clone 4A12. Western blot of EPM2A expression in PC-12.
Detection limit for recombinant GST tagged EPM2A is approximately 3 ng/ml as a capture antibody.
Showing 1-25 of 67 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).