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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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EPM2A / Laforin

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.

Gene Name: epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Family/Subfamily: Protein Phosphatase , Laforin
Synonyms: EPM2A, EPM2, LAFPTPase, LDE, Lafora PTPase, MELF, Laforin, LD
Target Sequences: NM_005670 NP_005661.1 O95278


EPM2A / Laforin Antibody - Anti-EPM2A antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Goat Polyclonal to Human EPM2A / Laforin
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
EPM2A / Laforin Antibody - Anti-EPM2A / Laforin antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $545.00
EPM2A / Laforin Antibody - Anti-EPM2A / Laforin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Bovine, Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
EPM2A / Laforin Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with EPM2A antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human EPM2A / Laforin
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG2b) to Human EPM2A / Laforin
Human
ELISA, Flo, ICC, IF, IHC, IP, RIA, WB
Unconjugated
100µg   $650.00
EPM2A / Laforin Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
EPM2A / Laforin Antibody - Immunofluorescence analysis of A549 cells.
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
EPM2A / Laforin Antibody
Select
Rabbit Polyclonal to Human EPM2A / Laforin
Human
ICC, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
EPM2A / Laforin Antibody - Western blot of immunized recombinant protein using EPM2A antibody.
Select
Mouse Monoclonal [clone 2323C3a] (IgG1) to Human EPM2A / Laforin
Human
DB, ICC, WB
Unconjugated
100µg   100µg/ml   $530.00
EPM2A / Laforin Antibody - Immunohistochemistry of paraffin-embedded human salivary gland using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $235.00; 100µl   $285.00
Select
Mouse Monoclonal [clone S84-37] (IgG1) to Human EPM2A / Laforin
Human
ICC, WB
Unconjugated
100µg   1mg/ml   $365.00
EPM2A / Laforin Antibody - Detection of Laforin in nueroblastoma cell line SK-N-BE with Laforin Monoclonal Antibody at 10ug/ml: DAPI (blue) nuclear stain, Texas Red F actin stain, ATTO 488 (green) Laforin stain.
Select
Mouse Monoclonal [clone S84-37] (IgG1) to Human EPM2A / Laforin
Human
IF, WB
Unconjugated
100µg   $425.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Human
ELISA, IHC
Unconjugated
200µl   $590.00
Select
Rabbit-New Zealand White Polyclonal to Mouse EPM2A / Laforin
Mouse, Human
IHC, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human EPM2A / Laforin
Mouse, Rat, Human
IF, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal to Human EPM2A / Laforin
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
EPM2A / Laforin Antibody - Cell lysates of HeLa and 293T (20 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human EPM2A (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Select
Mouse Monoclonal [clone K2A3] (IgG1) to Human EPM2A / Laforin
Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $345.00
EPM2A / Laforin Antibody - EPM2A monoclonal antibody (M01), clone 4A12. Western blot of EPM2A expression in PC-12.
Select
Mouse Monoclonal [clone 4A12] (IgG2a,k) to Human EPM2A / Laforin
Rat, Human
ELISA, WB
Unconjugated
100µg   $365.00
Viewing 1-25 of 68 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).