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EPHX2 / Epoxide Hydrolase 2

epoxide hydrolase 2, cytoplasmic

Soluble Epoxide Hydrolase (sEH) also known as cytosolic Epoxide Hydrolase is a phase I xenobiotic-metabolizing enzyme that converts epoxyeicosatrienoic acids (EETs) into their corresponding dihydroxyeicosatrienoic acids (DHETs). EETs are thought to be involved in vascular tone, ion channel regulation, mitogenesis and cell signaling. DHETs have, in general, less biological activity then EETs and are more readily excreted, thus hydration of EETs by sEH maybe a means of attenuating or eliminating their activity. sEHs have been identified in many tissues including liver, kidney, adrenal, pancreatic islets, gi tract and vascular smooth muscle.

Gene Name: epoxide hydrolase 2, cytoplasmic
Synonyms: EPHX2, CEH, Epoxide hydratase, Epoxide hydrolase, soluble, Epoxide hydrolase 2, cytosolic, SEH, Soluble epoxide hydrolase
Target Sequences: NM_001979 NP_001970.2 P34913

Publications (1)

1
Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis. Vengai Mavangira, Matthew J Kuhn, Angel Abuelo, Christophe Morisseau, Bruce D Hammock, Lorraine M Sordillo. Antioxidants (Basel, Switzerland). 2021 May;10: [Full Text Article] [PubMed:34065244] [PMC:PMC8161397] Related Antibodies: LS-B6940.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
EPHX2 / Epoxide Hydrolase 2 (6)
No (6)
GST (1)
GST, N-terminus (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
EPHX2 / Epoxide Hydrolase 2 Protein - Purified recombinant protein EPHX2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
62.4 kDa
20 µg/$1,107
EPHX2 / Epoxide Hydrolase 2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EPHX2 / Epoxide Hydrolase 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.4 kDa
100 µg/$494
EPHX2 / Epoxide Hydrolase 2 Protein
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E. coli
His-SUMO
78.57 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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293T Cells
Myc-DDK (Flag)
62.4 kDa
20 µg/$150
EPHX2 / Epoxide Hydrolase 2 Protein - 12.5% SDS-PAGE of human EPHX2 stained with Coomassie Blue
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Wheat Germ Extract
GST
89 kDa
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).