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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EPHB1 / EPH Receptor B1

EPH receptor B1

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Gene Name: EPH receptor B1
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHB1, Cek6, EK6, ELK, Ephrin type-B receptor 1, Hek6, EPHT2, NET, EPH receptor B1, EPH tyrosine kinase 2, EPH-like kinase 6, Soluble EPHB1 variant 1
Target Sequences: NM_004441 NP_004432.1 P54762

Filtered By: None
Target
EPHB1 / EPH Receptor B1 (30)
Reactivity
Human (26)
Mouse (19)
Rat (8)
Bat (1)
Bovine (1)
Chicken (1)
Guinea pig (1)
Horse (1)
Monkey (2)
Pig (1)
Sheep (1)
Application
IHC (14)
IHC-Fr (2)
IHC-P (4)
WB (24)
ELISA (14)
IF (1)
IP (3)
Host
rabbit (22)
mouse (4)
hamster (1)
sheep (3)
Isotype
IgG (14)
IgG1 (2)
IgG2a,k (1)
Clonality
monoclonal mc (4)
polyclonal pc (26)
Clone
4G6 (1)
5F10A4 (1)
EfB1-3 (1)
EfrnB1 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (24)
Epitope
aa955-984 (8)
C-Terminus (2)
aa304-339 (2)
810-890 aa, C-terminal (1)
N-Terminus (1)
aa374-409 (1)
aa56-88 (1)
Publications
No (30)
Showing 1-25 of 30 results

EPHB1 / EPH Receptor B1 Antibody (aa955-984) LS-C100280
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Mouse, Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Immunohistochemical of EphB1 in gastric cancer tissues. a EphB1 protein expressed in normal mucosa at the glandular compartment and in a decreasing gradient from the glandular compartment to the foveolar compartment. b EphB1 protein focally positively stained in well-differentiated gastric cancer cells. c EphB1 protein is focally positive in poorly differentiated gastric cancer cells. d Loss of EphB1 expression in gastric cancer cells.(Provided by Jian-dong Wang,Department of Pathology Nanjing Jinling Hospital/Nanjing University School of Medicine)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Immunohistochemical of EphB1 in gastric cancer tissues. a EphB1 protein expressed in normal mucosa at the glandular compartment and in a decreasing gradient from the glandular compartment to the foveolar compartment. b EphB1 protein focally positively stained in well-differentiated gastric cancer cells. c EphB1 protein is focally positive in poorly differentiated gastric cancer cells. d Loss of EphB1 expression in gastric cancer cells.(Provided by Jian-dong Wang,Department of Pathology Nanjing Jinling Hospital/Nanjing University School of Medicine)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

EPHB1 / EPH Receptor B1 Antibody (clone EfrnB1) LS-C209599
Hamster Monoclonal [clone EfrnB1] (IgG) to Mouse EPHB1 / EPH Receptor B1
Mouse
IF IHC IHC-Fr WB
Unconjugated
100µg 0.1mg/ml  $465.00

EPHB1 / EPH Receptor B1 Antibody (clone EfB1-3) LS-C209598
Mouse Monoclonal [clone EfB1-3] (IgG1) to Mouse EPHB1 / EPH Receptor B1
Mouse
IHC IHC-Fr WB
Unconjugated
100µg 0.1mg/ml  $465.00

EPHB1 / EPH Receptor B1 Antibody (clone 5F10A4) LS-C108795
Mouse Monoclonal [clone 5F10A4] (IgG1) to Human EPHB1 / EPH Receptor B1
Human
ELISA IHC WB
Unconjugated
100µl  $375.00
IHC of paraffin-embedded human lung cancer (left) and colon cancer (right) showing cytoplasmic localization with DAB staining using EphB1 mouse monoclonal antibody.
Western blot using EhpB1 mouse monoclonal antibody against MDA-MB-468 (1), MDA-MB-453 (2), MCF-7 (3), T47D (4) and SKBR-3 (5) cell lysate.
IHC of paraffin-embedded human lung cancer (left) and colon cancer (right) showing cytoplasmic localization with DAB staining using EphB1 mouse monoclonal antibody.
Western blot using EhpB1 mouse monoclonal antibody against MDA-MB-468 (1), MDA-MB-453 (2), MCF-7 (3), T47D (4) and SKBR-3 (5) cell lysate.

EPHB1 / EPH Receptor B1 Antibody (aa955-984) LS-C330430
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, Biotin) LS-C219021
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, FITC) LS-C219022
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, AP) LS-C219019
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, APC) LS-C219020
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, Azide-free, HRP) LS-C219023
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody (aa955-984, PE) LS-C219024
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

EPHB1 / EPH Receptor B1 Antibody LS-C675713
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Human
ELISA IHC IHC-P
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100

EPHB1 / EPH Receptor B1 Antibody (aa56-88) LS-C407798
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Mouse, Guinea pig, Human
IHC IHC-P WB
Unconjugated
100µg  $355.00
Eph receptor B1 antibody IHC-paraffin. IHC(P): Human Glioma Tissue.
Eph receptor B1 antibody Western blot. All lanes: Anti Eph receptor B1 at 0.5 ug/ml. WB: 293T Whole Cell Lysate at 40 ug. Predicted band size: 111 kD. Observed band size: 111 kD.
Eph receptor B1 antibody IHC-paraffin. IHC(P): Human Glioma Tissue.
Eph receptor B1 antibody Western blot. All lanes: Anti Eph receptor B1 at 0.5 ug/ml. WB: 293T Whole Cell Lysate at 40 ug. Predicted band size: 111 kD. Observed band size: 111 kD.

EPHB1 / EPH Receptor B1 Antibody LS-C490259
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Human
IHC IHC-P WB
Unconjugated
100µg  $365.00
Immunohistochemistry - Paraffin Image
Western blot Image
Immunohistochemistry - Paraffin Image
Western blot Image

EPHB1 / EPH Receptor B1 Antibody (clone 4G6) LS-C197146
Mouse Monoclonal [clone 4G6] (IgG2a,k) to Human EPHB1 / EPH Receptor B1
Human
ELISA WB
Unconjugated
100µg  $355.00
Western Blot analysis of EPHB1 expression in transfected 293T cell line by EPHB1 monoclonal antibody (M01), clone 4G6.Lane 1: EPHB1 transfected lysate (Predicted MW: 109.9 KDa).Lane 2: Non-transfected lysate.
Detection limit for recombinant GST tagged EPHB1 is 0.03 ng/ml as a capture antibody.
Western Blot analysis of EPHB1 expression in transfected 293T cell line by EPHB1 monoclonal antibody (M01), clone 4G6.Lane 1: EPHB1 transfected lysate (Predicted MW: 109.9 KDa).Lane 2: Non-transfected lysate.
Detection limit for recombinant GST tagged EPHB1 is 0.03 ng/ml as a capture antibody.

EPHB1 / EPH Receptor B1 Antibody LS-C742814
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Rat, Human
ELISA WB
Unconjugated
50µg 1mg/ml  $265.00; 100µg 1mg/ml  $325.00

EPHB1 / EPH Receptor B1 Antibody (810-890 aa, C-terminal) LS-C383370
Rabbit Polyclonal (IgG) to Human EPHB1 / EPH Receptor B1
Mouse, Rat, Human, Monkey
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of EphB1 antibody
Western blot of EphB1 antibody

EPHB1 / EPH Receptor B1 Antibody (aa304-339) LS-C344506
Rabbit Polyclonal to Mouse EPHB1 / EPH Receptor B1
Mouse, Rat
WB
Unconjugated
400µl  $305.00
Western blot of lysates from mouse NIH/3T3 cell line, mouse brain, mouse heart, mouse pancreas, rat brain tissue (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
Western blot of lysates from mouse NIH/3T3 cell line, mouse brain, mouse heart, mouse pancreas, rat brain tissue (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

EPHB1 / EPH Receptor B1 Antibody (aa374-409) LS-C344556
Rabbit Polyclonal to Mouse EPHB1 / EPH Receptor B1
Mouse, Rat, Human
WB
Unconjugated
400µl  $305.00
Western blot of lysates from A431, mouse NIH/3T3 cell line, mouse brain, rat brain tissue lysate (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
Western blot of lysates from A431, mouse NIH/3T3 cell line, mouse brain, rat brain tissue lysate (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

EPHB1 / EPH Receptor B1 Antibody (aa304-339) LS-C344653
Rabbit Polyclonal to Mouse EPHB1 / EPH Receptor B1
Mouse, Rat
WB
Unconjugated
400µl  $305.00
Western blot of lysates from mouse NIH/3T3 cell line, mouse brain, mouse heart, mouse pancreas, rat brain tissue lysate (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
Western blot of lysates from mouse NIH/3T3 cell line, mouse brain, mouse heart, mouse pancreas, rat brain tissue lysate (from left to right) with Ephb1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

EPHB1 / EPH Receptor B1 Antibody LS-C486157
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Human
ELISA
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

EPHB1 / EPH Receptor B1 Antibody LS-C486155
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Human
ELISA
Unconjugated
50µl  $275.00; 100µl  $355.00

EPHB1 / EPH Receptor B1 Antibody LS-C100281
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Human
WB
Unconjugated
400µl  $305.00
Western blot of EphB1 (arrow) using rabbit polyclonal EphB1 Antibody 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EphB1 gene (Lane 2) (Origene Technologies).
Western blot of EphB1 (arrow) using rabbit polyclonal EphB1 Antibody 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EphB1 gene (Lane 2) (Origene Technologies).

EPHB1 / EPH Receptor B1 Antibody (C-Terminus) LS-C368583
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Mouse, Rat, Human, Monkey
WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Western blot analysis of EPHB1 expression in MDA-MB-435 (A); U87MG (B); COS7 (C) whole cell lysates.
Western blot analysis of EPHB1 expression in MDA-MB-435 (A); U87MG (B); COS7 (C) whole cell lysates.

EPHB1 / EPH Receptor B1 Antibody LS-C417056
Rabbit Polyclonal to Human EPHB1 / EPH Receptor B1
Mouse, Rat, Human
WB
Unconjugated
100µg 1mg/ml  $305.00
Western blot of EPHB1 expression in COS7 cells
Western blot of EPHB1 expression in COS7 cells
Showing 1-25 of 30 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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