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EPHA1 / EPH Receptor A1

EPH receptor A1

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Gene Name: EPH receptor A1
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHA1, EPH receptor A1, Ephrin type-A receptor 1, EPHT, ESK, EPH tyrosine kinase 1, HEpha1, Oncogene EPH, Soluble EPHA1 variant 1, Soluble EPHA1 variant 2, EPH tyrosine kinase, EPHT1
Target Sequences: NM_005232 NP_005223.4 P21709

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Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
EPHA1 / EPH Receptor A1 (12)
No (12)
6His, C-terminus (1)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc (1)
GST, N-terminus (1)
His,C-terminus (2)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (9)
Mouse (2)
293T Cells (1)
E. coli (2)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (4)
EPHA1 / EPH Receptor A1 Protein - Purified recombinant protein EPHA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
107.9 kDa
20 µg/$1,107
EPHA1 / EPH Receptor A1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
83.3 kDa
100 µg/$793
EPHA1 / EPH Receptor A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
107.9 kDa
100 µg/$710
EPHA1 / EPH Receptor A1 Protein - Recombinant Ephrin Type A Receptor 1 By SDS-PAGE
Select
E. coli
His-T7
31.3 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
EPHA1 / EPH Receptor A1 Protein - Recombinant Ephrin Type A Receptor 1 By SDS-PAGE
Select
E. coli
His-T7
31.6 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.4kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
EPHA1 / EPH Receptor A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
107.9 kDa
20 µg/$215
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
59 kDa
20 µg/$1,107
EPHA1 / EPH Receptor A1 Protein
Select
Sf9 Cells
DDK,C-terminus
56.5 kDa
20 µg/$677
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.6 kDa
100 µg/$793
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.4 kDa
10 µg/$281; 50 µg/$389
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).