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EP400 / p400
E1A binding protein p400
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
| Gene Name: | E1A binding protein p400 |
| Synonyms: | EP400, CAG repeat protein 32, DKFZP434I225, E1A binding protein p400, p400 SWI2/SNF2-related protein, p400, TNRC12, CAGH32, Domino homolog, E1A-binding protein p400, HDomino, KIAA1498, KIAA1818 |
| Target Sequences: | NM_015409 NP_056224.3 Q96L91 |
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