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Eomesodermin / EOMES

eomesodermin

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Gene Name: eomesodermin
Synonyms: EOMES, Eomesodermin, Eomesodermin homolog, T box, brain, 2, T-box brain protein 2, T-box brain2, T-brain-2, TBR-2, TBR2
Target Sequences: NM_005442 NP_005433.2 O95936

Publications (2)

1
Tbr2 is required to generate a neural circuit mediating the pupillary light reflex. Sweeney NT, Tierney H, Feldheim DA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 34:5447-53. (IHC; Mouse) [Full Text Article] [PubMed:24741035] [PMC:PMC3988404] Related Antibodies: LS-B6801.
2
Expression of transcription factors divides retinal ganglion cells into distinct classes. Sweeney NT, James KN, Nistorica A, Lorig-Roach RM, Feldheim DA. The Journal of comparative neurology. 2019 January;527:225-235. [Full Text Article] [PubMed:28078709] Related Antibodies: LS-B6801.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
Eomesodermin / EOMES (6)
No (6)
GST, N-terminus (2)
His, N-Terminal (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
Eomesodermin / EOMES Protein - Recombinant Eomesodermin (EOMES) by SDS-PAGE
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E. coli
His-GST, N-terminus
60.1kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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E. coli
His, N-Terminal
72.6 kDa
50 µg/$419
Eomesodermin / EOMES Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
72.6 kDa
20 µg/$215
Eomesodermin / EOMES Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Eomesodermin / EOMES Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Eomesodermin / EOMES Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
72.6 kDa
100 µg/$710
Viewing 1-6 of 6 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).