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Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Gene Name: | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
Family/Subfamily: | Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other |
Synonyms: | ENPP2, AUTOTAXIN, Autotaxin-t, ATX-X, E-NPP 2, LysoPLD, NPP2, PDNP2, PD-IALPHA, Plasma lysophospholipase D, Phosphodiesterase I alpha |
Target Sequences: | NM_006209 NP_006200.3 Q13822 |
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