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ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1

By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.

Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Family/Subfamily: Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other
Synonyms: ENPP1, Alkaline phosphodiesterase I, ARHR2, E-NPP 1, Ly-41 antigen, NPP1, NPPS, PC1, PDNP1, Alkaline phosphodiesterase 1, M6S1, PCA1, Pc-1
Target Sequences: NM_006208 NP_006199.2 P22413

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Products
Proteins (12)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Recombinant (7)
ENPP1 (12)
No (12)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His-GST (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (8)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
ENPP1 Protein - Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 By SDS-PAGE
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E. coli
His-GST, N-terminus
58.3 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
ENPP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ENPP1 Protein - 12.5% SDS-PAGE of human ENPP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
126.3 kDa
2 µg/$439
Select
HEK 293 Cells
6His, N-terminus
95 kDa
200 µl/$283
ENPP1 Protein - Purified recombinant protein ENPP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
99.8 kDa
20 µg/$1,107
ENPP1 Protein - Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 By SDS-PAGE
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E. coli
His
19.8 kDa
10 µg/$290; 50 µg/$497; 100 µg/$795; 200 µg/$992; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324
ENPP1 Protein - Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 By SDS-PAGE
Select
E. coli
His
19.4 kDa
10 µg/$290; 50 µg/$497; 100 µg/$795; 200 µg/$992; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324
ENPP1 Protein - Recombinant Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 By SDS-PAGE
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E. coli
His-GST
53.2 kDa
10 µg/$295; 50 µg/$527; 100 µg/$842; 200 µg/$1,042; 1 mg/$2,206; 500 µg/$1,724; 5 mg/$3,683; 2 mg/$2,397
ENPP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
99.8 kDa
100 µg/$494
ENPP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
99.93 kDa
100 µg/$710
ENPP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
99.93 kDa
20 µg/$215
ENPP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
99.8 kDa
20 µg/$150
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).