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By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.
|Gene Name:||ectonucleotide pyrophosphatase/phosphodiesterase 1|
|Family/Subfamily:||Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other|
|Synonyms:||ENPP1, Alkaline phosphodiesterase I, ARHR2, E-NPP 1, Ly-41 antigen, NPP1, NPPS, PC1, PDNP1, Alkaline phosphodiesterase 1, M6S1, PCA1, Pc-1|
|Target Sequences:||NM_006208 NP_006199.2 P22413|
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