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Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Gene Name: | essential meiotic structure-specific endonuclease 1 |
Synonyms: | EME1, MMS4, MMS4L, MMS4 homolog, SLX2A, HMMS4 |
Target Sequences: | NP_001159603.1 Q96AY2 |
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