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EMA / MUC1

mucin 1, cell surface associated

EMA / MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Gene Name: mucin 1, cell surface associated
Family/Subfamily: Mucin , not assigned-Mucin
Synonyms: MUC1, CA15-3, CD227, Carcinoma-associated mucin, CD227 antigen, DF3 antigen, Episialin, Epithelial membrane antigen, H23 antigen, H23AG, Krebs von den Lungen-6, MAM6, MUC1/ZD, MUC-1/SEC, Mucin-1, Pem, KL-6, MUC-1/X, Tumor-associated mucin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, PUM, EMA, MUC-1, Mucin 1, transmembrane
Target Sequences: NM_002456 NP_002447.4 P15941

Publications (7)

1
Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden. Kwon WS, Kim TS, Nahm CH, Moon Y, Kim JJ. Oncology letters. 2018 November;16:5583-5590. [Full Text Article] [PubMed:30344712] [PMC:PMC6176264]
2
Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. Elena Zagato , Chiara Pozzi , Alice Bertocchi, Tiziana Schioppa, Fabiana Saccheri, Silvia Guglietta, Bruno Fosso, Laura Melocchi, Giulia Nizzoli, Jacopo Troisi, Marinella Marzano, Bianca Oresta, Ilaria Spadoni, Koji Atarashi, Sara Carloni, Stefania Arioli, Giulia Fornasa, Francesco Asnicar, Nicola Segata, Simone Guglielmetti, Kenya Honda, Graziano Pesole, William Vermi, Giuseppe Penna, Maria Rescigno. Nature microbiology. 2020 March;5:511-524. [Full Text Article] [PubMed:31988379] [PMC:PMC7048616] Related Antibodies: LS-C343984.
3
Serum concentration of sex hormone-binding globulin in healthy volunteers and patients with breast cancer stratified by sex and age. Se Jung Park, Tae Soo Kim, Kyu Hyun Park, Woo Sun Kwon, Jin Ju Kim. Oncology letters. 2020 July;20:364-372. [Full Text Article] [PubMed:32565962] [PMC:PMC7285803]
4
Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis. Irina G Luzina, Erik P Lillehoj, Virginia Lockatell, Sang W Hyun, Katerina N Lugkey, Akihiro Imamura, Hideharu Ishida, Christopher W Cairo, Sergei P Atamas, Simeon E Goldblum. The Journal of pharmacology and experimental therapeutics. 2020 November; [Full Text Article] [PubMed:33139318] [PMC:PMC7788353] Related Antibodies: LS-C343984.
5
Sublethal Radiation Affects Antigen Processing and Presentation Genes to Enhance Immunogenicity of Cancer Cells. Achamaporn Punnanitinont, Eric D Kannisto, Junko Matsuzaki, Kunle Odunsi, Sai Yendamuri, Anurag K Singh, Santosh K Patnaik. International journal of molecular sciences. 2020 Apr;21:2573. [Full Text Article] [PubMed:32272797] [PMC:PMC7178186] Related Antibodies: LS-B2244.
6
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma. Carolina Martinelli, Fabio Gabriele, Federico Manai, Roberto Ciccone, Francesca Novara, Elisabetta Sauta, Riccardo Bellazzi, Monica Patane, Isabella Moroni, Rosina Paterra, Sergio Comincini. Cancer genomics & proteomics. 2020 Mar-Apr;17:117-130. [Full Text Article] [PubMed:32108034] [PMC:PMC7078841] Related Antibodies: LS-C77445.
7
Immunohistochemical characterization of mesothelioma in 6 large felids. Sarah E Coe, Michael M Garner, Matti Kiupel. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2021 July;33:767-771. [Full Text Article] [PubMed:33980074] [PMC:PMC8229833] Related Antibodies: LS-C30532.
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Antibodies (339)
Primary (339)
EMA / MUC1 (339)
Human (293)
Mouse (71)
Rat (31)
Bat (6)
Bovine (13)
Chimpanzee (6)
Duck (1)
Gibbon (6)
Goat (6)
Guinea pig (4)
Hamster (3)
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Monkey (6)
Pig (13)
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IHC (180)
IHC-Fr (44)
IHC-P (133)
WB (162)
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DB (14)
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EM (4)
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IF (82)
IP (9)
Peptide-ELISA (8)
PMA (2)
rabbit (166)
mouse (167)
mouse-balb/c (6)
Product Group
IHCPlus (17)
PathPlus Cancer (9)
PathPlus Cancer Pathology (9)
IgG (92)
IgG,k (1)
IgG,l (2)
IgG1 (67)
IgG1 + IgG2a (3)
IgG1,k (39)
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monoclonal mc (169)
polyclonal pc (156)
recombinant monoclonal rmc (14)
003 (1)
05 (1)
115D8 (3)
139H2 (5)
175C5 (2)
1B7 (1)
214D4 (2)
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Concentrated (13)
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Cy7 Conjugated (7)
FITC Conjugated (31)
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Ready-to-Use (15)
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Unconjugated (197)
C-Terminus (17)
aa410-525 (16)
pTyr1229 (12)
aa474-630 (11)
aa1034-1151 (9)
aa1-350 (8)
aa1098-1255 (8)
aa404-655 (8)
aa1176-1205 (7)
aa1202-1231 (7)
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aa1191-1240 (1)
aa1192-1241 (1)
aa1196-1245 (1)
aa1201-1250 (1)
aa1204-1253 (1)
aa935-1097 (1)
pSer1227 (1)
No (335)
Yes (4)
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EMA / MUC1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IF, IHC, IHC-P
FITC Conjugated
50 µg/$485
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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EMA / MUC1 Mouse anti-Human Monoclonal (GP1.4) Antibody
Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
EMA / MUC1 Antibody - MUC1 antibody IHC-paraffin: Rat Kidney Tissue.
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EMA / MUC1 Rabbit anti-Mouse Polyclonal (aa474-630) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
EMA / MUC1 Antibody - MUC1 / Episialin antibody ARP41445_P050-NP_001037855-MUC1(mucin 1, cell surface associated) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EMA / MUC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
EMA / MUC1 Antibody - Anti-EMA / MUC1 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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EMA / MUC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
EMA / MUC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
250 µl/$485
Select
EMA / MUC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
200 µg/$798
Select
EMA / MUC1 Mouse anti-Human Monoclonal (HRP) (C595 (NCRC48)) Antibody
Human
ELISA, Flo, IF, IHC, WB
HRP Conjugated
100 µl/$1,025
Select
EMA / MUC1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
100 µl/$1,025
EMA / MUC1 Antibody - MUC1 / Episialin antibody ARP41446_T100-NP_001037855-MUC1(mucin 1, cell surface associated) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EMA / MUC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
EMA / MUC1 Antibody - Anti-EMA / MUC1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer Pathology
Cancer
EMA / MUC1 Mouse anti-Human Monoclonal (VU-4H5) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$485
EMA / MUC1 Antibody - Human Pancreas, Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
EMA / MUC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P
Unconjugated
0.5 mg/$585
Select
EMA / MUC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
1 mg/$1,288
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
EMA / MUC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
EMA / MUC1 Antibody - IHC testing of FFPE human stomach with MUC1 antibody (clone 115D8). HIER: requires steaming of sections in 10mM citrate buffer, pH 6, for 10-20 min.
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EMA / MUC1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (115D8) Antibody
Human
Flo, IF, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
EMA / MUC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$440
EMA / MUC1 Antibody - Immunohistochemical analysis of MUC1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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EMA / MUC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Select
Cancer Pathology
Cancer
EMA / MUC1 Mouse-Balb/c anti-Human Monoclonal (139H2) Antibody
Human
ELISA, EM, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$485
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC staining of human lung, Type 2 pneumocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Cancer Pathology
Cancer
EMA / MUC1 Mouse-Balb/c anti-Human Monoclonal (139H2) Antibody
Human
ELISA, EM, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$460
EMA / MUC1 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
EMA / MUC1 Mouse anti-Human Monoclonal (ABT-EMA) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$460
EMA / MUC1 Antibody - Immunohistochemistry-Paraffin: MUC1 Antibody - Human kidney lysate tissue at an antibody concentration of 4-8ug/ml.
Select
EMA / MUC1 Rabbit anti-Human Polyclonal (aa1192-1241) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Select
EMA / MUC1 Mouse-Balb/c anti-Human Monoclonal (175C5) Antibody
Human
ELISA, EM, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
EMA / MUC1 Mouse-Balb/c anti-Human Monoclonal (175C5) Antibody
Human
ELISA, EM, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$460
EMA / MUC1 Antibody - IHC of paraffin-embedded Human breast tissue using anti-MUC1 mouse monoclonal antibody.
Select
EMA / MUC1 Mouse anti-Human Monoclonal (OTI2F6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
EMA / MUC1 Antibody - Anti-MUC1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
EMA / MUC1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.25 mg/$615
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).