ELAVL1 / HUR

ELAV like RNA binding protein 1

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

ELAVL1 / HUR (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human ELAVL1 / HUR Protein (Recombinant 6His, N-terminus) (Ser2-Lys326) - LS-G96839

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

31 kDa

Price:

10 µg/$265; 50 µg/$315

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Human ELAVL1 / HUR Protein (Recombinant His, N-Terminal) (Ser2-Lys326) - LS-G96840

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

40 kDa-27 kDa

Price:

10 µg/$289; 200 µg/$646; 50 µg/$360

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Human ELAVL1 / HUR Protein (Recombinant GST) (Full Length) - LS-G28328

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.5 kDa

Price:

2 µg/$439

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Human ELAVL1 / HUR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76625

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$150

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Human ELAVL1 / HUR Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G58437

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ELAVL1 / HUR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65952

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

20 µg/$1,107

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ELAVL1 / HUR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99433

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.9 kDa

Price:

100 µg/$494

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