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EKLF / KLF1

Kruppel-like factor 1 (erythroid)

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

Gene Name: Kruppel-like factor 1 (erythroid)
Synonyms: KLF1, Erythroid Kruppel-like factor, HBFQTL6, INLU, Krueppel-like factor 1, Monoclonal antibody A3D8, EKLF
Target Sequences: NM_006563 NP_006554.1 Q13351

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EKLF / KLF1 ELISA Kit
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15.63 - 1000 pg/ml
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).