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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.
Gene Name: | eukaryotic translation initiation factor 3, subunit G |
Synonyms: | EIF3G, EIF3 p44, EIF3-delta, EIF3-P42, EIF3-p44, EIF-3-delta, EIF-3 RNA-binding subunit, EIF3S4, EIF3 p42 |
Target Sequences: | NM_003755 NP_003746.2 O75821 |
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