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EIF2AK3 / PERK
eukaryotic translation initiation factor 2-alpha kinase 3
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
| Gene Name: | eukaryotic translation initiation factor 2-alpha kinase 3 |
| Family/Subfamily: | Protein Kinase , Translational Control Kinase |
| Synonyms: | EIF2AK3, HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PERK, PKR-like ER kinase, WRS |
| Target Sequences: | NM_004836 NP_004827.4 Q9NZJ5 |
Publications (3)
1
Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2a-dependent translational attenuation and insulin biosynthesis in pancreatic ß cells. Akai R, Hosoda A, Yoshino M, Iwawaki T. Genes to cells : devoted to molecular & cellular mechanisms. 2015 November;20:871-86. [Full Text Article]
[PubMed:26314560]
2
Linagliptin and Vitamin D3 Synergistically Rescue Testicular Steroidogenesis and Spermatogenesis in Cisplatin-Exposed Rats: The Crosstalk of Endoplasmic Reticulum Stress with NF-?B/iNOS Activation. Rania A Elrashidy, Esraa M Zakaria, Asmaa M Elmaghraby, Rasha E M Abd El Aziz, Ranya M Abdelgalil, Rehab M Megahed, Asmaa A Elshiech, Doaa E A Salama, Samah E Ibrahim. Molecules (Basel, Switzerland). 2022 October;27: [Full Text Article]
[PubMed:36364125]
[PMC:PMC9657441]
3
Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Vong CT, Tseng HH, Kwan YW, Lee SM, Hoi MP. Frontiers in pharmacology. 2016 7:67. (WB; Human)
[Full Text Article]
[PubMed:27047382]
[PMC:PMC4800184]
Related Antibodies: LS-C118320.
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EIF2AK3 / PERK Rabbit anti-Mouse Monoclonal (pThr980) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µl/$689
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa947-996) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa148-175) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
EIF2AK3 / PERK Mouse anti-Human Monoclonal (1385CT582.4.39) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
200 µl/$393
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (920-1000 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa73-102) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa73-102) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa73-102) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (pThr981) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
EIF2AK3 / PERK Mouse anti-Human Monoclonal (5G5) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
EIF2AK3 / PERK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
293T Cells
Myc-DDK (Flag)
125.26 kDa
20 µg/$215
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (Arg87) Antibody
Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (920-1000 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
EIF2AK3 / PERK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
EIF2AK3 / PERK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
EIF2AK3 / PERK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (p981) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
EIF2AK3 / PERK Rabbit anti-Human Polyclonal (aa61-110) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
EIF2AK3 / PERK Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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