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EIF2A / EIF2 Alpha

eukaryotic translation initiation factor 2A, 65kDa

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.

Gene Name: eukaryotic translation initiation factor 2A, 65kDa
Synonyms: EIF2A, CDA02, EIF2 alpha, MSTP004, MSTP089, EIF-2A, MST089
Target Sequences: NM_032025 NP_114414.2 Q9BY44

Publications (1)

1
Tumor necrosis factor-a triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways. Denis Selimovic, Renate U Wahl, Emmanuelle Ruiz, Rizwan Aslam, Thomas W Flanagan, Sofie-Yasmin Hassan, Simeon Santourlidis, Youssef Haikel, Paul Friedlander, Mosaad Megahed, Emad Kandil, Mohamed Hassan. International journal of oncology. 2019 December;55:1324-1338. [Full Text Article] [PubMed:31638203]

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Proteins (4)
Over-Expression Lysate (2)
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EIF2A / EIF2 Alpha (4)
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GST (1)
Myc-DDK (Flag) (3)
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293T Cells (1)
HEK 293 Cells (2)
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Purified (1)
EIF2A / EIF2 Alpha Protein - 12.5% SDS-PAGE of human EIF2A stained with Coomassie Blue
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Wheat Germ Extract
GST
91.4 kDa
2 µg/$439
EIF2A / EIF2 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
64.8 kDa
100 µg/$494
EIF2A / EIF2 Alpha Protein - Purified recombinant protein EIF2A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
64.8 kDa
20 µg/$1,107
EIF2A / EIF2 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
64.8 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).