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EGFR

epidermal growth factor receptor

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.

Gene Name: epidermal growth factor receptor
Family/Subfamily: Protein Kinase , EGF Receptor
Synonyms: EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1
Target Sequences: NM_005228 NP_005219.2 P00533

Publications (11)

1
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L314-27. (WB) [PubMed:17468132]
2
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells. Kumar N, Afeyan R, Kim HD, Lauffenburger DA. Molecular pharmacology. 2008 73:1668-78. (ICC) [PubMed:18349105]
3
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU, Bae SS, Kim CD. Toxicology and applied pharmacology. 2010 245:76-82. (WB) [PubMed:20153347]
4
Nuclear translocation of type I transforming growth factor receptor confers a novel function in RNA processing. Chandra M, Zang S, Li H, Zimmerman LJ, Champer J, Tsuyada A, Chow A, Zhou W, Yu Y, Gao H, Ren X, Lin RJ, Wang SE. Molecular and cellular biology. 2012 32:2183-95. [PubMed:22473997] [PMC:PMC3372271]
5
Liquid crystal droplet-based amplification of microvesicles that are shed by mammalian cells. Tan LN, Wiepz GJ, Miller DS, Shusta EV, Abbott NL. The Analyst. 2014 139:2386-96. (WB; Human) [Full Text Article] [PubMed:24667742] [PMC:PMC4212983]
6
HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone. Day KC, Lorenzatti Hiles G, Kozminsky M, Dawsey SJ, Paul A, Broses LJ, Shah R, Kunja LP, Hall C, Palanisamy N, Daignault-Newton S, El-Sawy L, Wilson SJ, Chou A, Ignatoski KW, Keller E, Thomas D, Nagrath S, Morgan T, Day ML. Cancer research. 2017 77:74-85. (IP; Human) [Full Text Article] [PubMed:27793843] [PMC:PMC5214538]
7
Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody. Reilly EB, Phillips AC, Buchanan FG, Kingsbury G, Zhang Y, Meulbroek JA, Cole TB, DeVries PJ, Falls HD, Beam C, Gu J, Digiammarino EL, Palma JP, Donawho CK, Goodwin NC, Scott AM. Molecular cancer therapeutics. 2015 14:1141-51. (WB; Human) [Full Text Article] [PubMed:25731184] Related Antibodies: LS-C6625.
8
Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK. Carcinogenesis. 2013 34:2716-25. (IP; Human) [Full Text Article] [PubMed:23892603]
9
Increased PD-L1 expression in erlotinib-resistant NSCLC cells with MET gene amplification is reversed upon MET-TKI treatment. Christina Demuth, Morten Nørgaard Andersen, Kristine Raaby Jakobsen, Anne Tranberg Madsen, Boe Sandahl Sørensen. Oncotarget. 2017 September;8:68221-68229. [Full Text Article] [PubMed:28978110] [PMC:PMC5620250] Related Antibodies: LS-C6611.
10
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Nature. 2013 Jul;499:166-71. [Full Text Article] [PubMed:23846654] Related Antibodies: LS-C6640.
11
Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy. Aggerholm-Pedersen N, Demuth C, Safwat A, Meldgaard P, Kassem M, Sandahl Sorensen B. Stem cells international. 2016 2016:9601493. (WB; Human) [Full Text Article] [PubMed:26788073] [PMC:PMC4693025] Related Antibodies: LS-C6611.
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No (537)
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EGFR Antibody - Anti-EGFR antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer Pathology
Cancer
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EGFR Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
EGFR Antibody - Anti-EGFR antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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EGFR Sheep anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$595
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EGFR Sheep anti-Human Polyclonal (Biotin) Antibody
Chicken, Mouse, Rat, Human
ELISA, ICC, IF, IP, WB
Biotin Conjugated
100 µl/$919
EGFR Antibody - Anti-EGFR antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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EGFR Sheep anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
EGFR Antibody - Immunohistochemical analysis of EGFR (pT693) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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EGFR Rabbit anti-Human Polyclonal (pThr693) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
EGFR Antibody - IHC of EGFR on FFPE Colon Carcinoma tissue.
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EGFR Mouse anti-Human Monoclonal (31G7) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$332; 0.5 ml/$570; 1 ml/$797
EGFR Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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EGFR Rabbit anti-Human Polyclonal (aa27-57) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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EGFR Mouse anti-Human Monoclonal (31G7) Antibody
Human
IHC, IHC-P
Unconjugated
0.5 ml/$415; 1 ml/$550
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EGFR Rat anti-Human Monoclonal (Extracellular Domain) (FITC) (ICR10) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$444
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EGFR Rabbit anti-Human Polyclonal (pTyr1068) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$717
EGFR Antibody - IHC of paraffin-embedded cervical cancer tissues using EGFR mutant mouse monoclonal antibody with DAB staining.
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EGFR Mouse anti-Human Monoclonal (aa693-893) (5G9B5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
EGFR Antibody - Anti-EGFR antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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EGFR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
EGFR Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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EGFR Rabbit anti-Human Polyclonal (Ser1070) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
EGFR Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using EGFR Antibody. The picture on the right is blocked with the synthesized peptide.
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EGFR Rabbit anti-Human Polyclonal (aa986-1035) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
EGFR Antibody - IHC of EGFR (S1166) pAb in paraffin-embedded human breast carcinoma tissue.
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EGFR Rabbit anti-Human Polyclonal (Ser1166) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
EGFR Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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EGFR Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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EGFR Mouse anti-Human Monoclonal (pTyr1173) Antibody
Mouse, Dog, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$845
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EGFR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µl/$702
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EGFR Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
EGFR Antibody - Staining of A431 cells with Rat anti-Human EGF Receptor (RAT ANTI HUMAN EGF RECEPTOR).
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EGFR Rat anti-Human Monoclonal (Extracellular Domain) (ICR10) Antibody
Human
Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.2 mg/$486
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EGFR Rabbit anti-Human Polyclonal (aa1004-1033) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
EGFR Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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EGFR Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Zebrafish, Pig, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
EGFR Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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EGFR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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EGFR Rat anti-Human Monoclonal (Extracellular Domain) (423103) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$896
EGFR Antibody
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EGFR Mouse anti-Human Monoclonal (AT6E3) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).