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EGFL7

EGF-like-domain, multiple 7

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

Gene Name: EGF-like-domain, multiple 7
Synonyms: EGFL7, EGF-like-domain, multiple 7, RP11-251M1.2, VE-STATIN, NOTCH4-like protein, ZNEU1, EGF-like protein 7, MEGF7, Vascular endothelial statin
Target Sequences: NM_016215 NP_057299.1 Q9UHF1

Publications (2)

1
EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia. Marius Bill, Aparna Pathmanathan, Malith Karunasiri, Changxian Shen, Matthew H Burke, Parvathi Ranganathan, Dimitrios Papaioannou, Nina C Zitzer, Katiri Snyder, Allison LaRocco, Allison E Walker, Zachary J Brannan, Ansel P Nalin, Aharon G Freud, Mikhail M Dikov, Xiaoli Zhang, Clara D Bloomfield, Ramiro Garzon, Adrienne M Dorrance. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 February;26:669-678. [Full Text Article] [PubMed:31672772] Related Antibodies: LS-C153302, LS-C40134.
2
Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia. Dimitrios Papaioannou, Changxian Shen, Deedra Nicolet, Betina McNeil, Marius Bill, Malith Karunasiri, Matthew H Burke, Hatice Gulcin Ozer, Selen A Yilmaz, Nina Zitzer, Gregory K Behbehani, Christopher C Oakes, Damian J Steiner, Guido Marcucci, Bayard L Powell, Jonathan E Kolitz, Thomas H Carter, Eunice S Wang, Krzysztof Mrózek, Carlo M Croce, Michael A Caligiuri, Clara D Bloomfield, Ramiro Garzon, Adrienne M Dorrance. Proceedings of the National Academy of Sciences of the United States of America. 2017 June;114:E4641-E4647. [Full Text Article] [PubMed:28533390] [PMC:PMC5468639] Related Antibodies: LS-C153302, LS-C40134.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).