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EFNB2 / Ephrin B2

ephrin-B2

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Gene Name: ephrin-B2
Family/Subfamily: Ephrin , Not assigned-Other
Synonyms: EFNB2, Ephrin-B2, EPLG5, Ephrin B2, HTK ligand, Htk-L, LERK-5, LERK5, Ligand of eph-related kinase 5, HTKL
Target Sequences: NM_004093 NP_004084.1 P52799

Publications (1)

1
The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study. Shin Taek Oh, Keum Jin Yang, Jung Min Bae, Hyun Jeong Park, Dong Soo Yoo, Young Min Park. International journal of dermatology. 2021 June;60:736-741. [Full Text Article] [PubMed:33598934] Related Antibodies: LS-C403980.

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Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
EFNB2 / Ephrin B2 (11)
No (11)
6His, C-terminus (2)
Fc/6His,C-terminus (1)
Fc-6His, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (2)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (4)
EFNB2 / Ephrin B2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.7 kDa
100 µg/$494
EFNB2 / Ephrin B2 Protein - 12.5% SDS-PAGE of human EFNB2 stained with Coomassie Blue
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Wheat Germ Extract
GST
63.3 kDa
10 µg/$479; 25 µg/$670
EFNB2 / Ephrin B2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.7 kDa
20 µg/$150
EFNB2 / Ephrin B2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EFNB2 / Ephrin B2 Protein - Purified recombinant protein EFNB2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
36.7 kDa
20 µg/$1,107
EFNB2 / Ephrin B2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.6 kDa
10 µg/$229; 50 µg/$262
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.2 kDa
10 µg/$233; 50 µg/$269
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.6kD
10 µg/$229; 50 µg/$262; 500 µg/$544; 1 mg/$725
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.24kD
10 µg/$233; 50 µg/$266; 500 µg/$929; 1 mg/$1,245
EFNB2 / Ephrin B2 Protein - Recombinant Ephrin B2 By SDS-PAGE
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E. coli
His-GST
64.3 kDa
10 µg/$260; 50 µg/$335; 100 µg/$497; 200 µg/$622; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).