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EDR / PEG10

paternally expressed 10

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene.

Gene Name: paternally expressed 10
Synonyms: PEG10, HB-1, MART2, Mar2, MEF3 like 1, MEF3-like protein 1, MEF3L1, KIAA1051, RGAG3, MEF3L, Ty3/Gypsy-like protein, EDR, Paternally expressed 10
Target Sequences: AX082622 CAC33259.1 Q86TG7

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Products
Antibodies (35)
Primary (35)
EDR / PEG10 (35)
Human (35)
Mouse (2)
Bovine (6)
Chimpanzee (6)
Horse (3)
Monkey (3)
Pig (5)
Rabbit (5)
IHC (6)
IHC-P (3)
WB (33)
Flo (7)
ELISA (15)
ICC (2)
IF (5)
IP (3)
Peptide-ELISA (1)
rabbit (24)
mouse (11)
Product Group
IHCPlus (2)
IgG (14)
IgG1 (8)
monoclonal mc (11)
polyclonal pc (24)
1B1C4 (2)
4C10A7 (2)
OTI1G10 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (21)
aa1-30 (7)
aa123-172 (4)
aa324-373 (4)
Amino Acid: 1-120 (1)
aa1-325 (1)
aa325-375 (1)
No (35)
EDR / PEG10 Antibody - Anti-PEG10 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
EDR / PEG10 Mouse anti-Human Monoclonal (4C10A7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
EDR / PEG10 Antibody - Anti-PEG10 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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EDR / PEG10 Mouse anti-Human Monoclonal (1B1C4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
EDR / PEG10 Antibody - Immunochemical staining of human PEG10 in human adrenal gland with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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EDR / PEG10 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P, IP, WB
Unconjugated
100 µl/$412
EDR / PEG10 Antibody - PEG10 Antibody western blot of U251 cell line lysates (35 ug/lane). The PEG10 antibody detected the PEG10 protein (arrow).
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EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
Flo, Peptide-ELISA, WB
Unconjugated
400 µl/$393
EDR / PEG10 Antibody - PEG10 Antibody in Immunohistochemistry (IHC)
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EDR / PEG10 Mouse anti-Human Monoclonal (Amino Acid: 1-120) (1B1C4) Antibody
Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$541
EDR / PEG10 Antibody - Western Blot (WB) analysis using PEG10 Monoclonal Antibody against HeLa cell lysate.
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EDR / PEG10 Mouse anti-Human Monoclonal Antibody
Rabbit, Mouse, Pig, Human
WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
EDR / PEG10 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human Placenta tissues with AEC staining using PEG10 Monoclonal Antibody.
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EDR / PEG10 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
Select
EDR / PEG10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
EDR / PEG10 Antibody - PEG10 Antibody in Immunohistochemistry (IHC)
Select
EDR / PEG10 Mouse anti-Human Monoclonal (4C10A7) Antibody
Human
IHC, WB
Unconjugated
100 µl/$541
EDR / PEG10 Antibody - Western blot detection of PEG10 in Hela cell lysates using PEG10 mouse mAb (1:1000 diluted). Predicted band size: 55KDa. Observed band size: 55KDa, 95KDa.
Select
EDR / PEG10 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
EDR / PEG10 Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PEG10 Antibody at dilution of 1:100
Select
EDR / PEG10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa1-325) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
EDR / PEG10 Antibody - Western blot detection of PEG10 in HeLa cell lysates using PEG10 mouse monoclonal antibody (1:1000 dilution). Predicted band size: 55KDa. Observed band size:55KDa, 95KDa.
Select
EDR / PEG10 Mouse anti-Human Monoclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$391
EDR / PEG10 Antibody - Western blot detection of PEG10 in Hela cell lysates using PEG10 antibody (1:1000 diluted).
Select
EDR / PEG10 Mouse anti-Human Monoclonal Antibody
Rabbit, Mouse, Pig, Human
WB
Unconjugated
50 µl/$356; 100 µl/$461
EDR / PEG10 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY PEG10. (Right lane) cDNA for 48 hrs and lysed
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EDR / PEG10 Mouse anti-Human Monoclonal (OTI1G10) Antibody
Human
WB
Unconjugated
100 µl/$434
EDR / PEG10 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY PEG10. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PEG10. (1:2000)(1:500)
Select
EDR / PEG10 Mouse anti-Human Monoclonal (Carrier-free) (OTI1G10) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
EDR / PEG10 Antibody - Western blot of Human Thyroid Tumor. PEG10 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EDR / PEG10 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
WB
Unconjugated
100 µl/$424
Viewing 1-25 of 35 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).