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Floor 6, Suite 620
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Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Gene Name: | ER degradation enhancer, mannosidase alpha-like 2 |
Synonyms: | EDEM2, BA4204.1, C20orf49, C20orf31 |
Target Sequences: | NM_018217 NP_060687.2 Q9BV94 |
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