ECT2

epithelial cell transforming sequence 2 oncogene

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

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Products

Antibodies (43)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (43)

Recombinant (4)

Target

ECT2 (49)

Reactivity

Human (43)

Mouse (9)

Rat (7)

Bat (3)

Bovine (3)

Chicken (1)

Chimpanzee (7)

Dog (7)

Gibbon (6)

Guinea pig (6)

Horse (3)

Monkey (7)

Rabbit (6)

Zebrafish (4)

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Application

IHC (12)

IHC-P (4)

WB (36)

ELISA (10)

IP (1)

Peptide-ELISA (1)

Host

rabbit (39)

mouse (3)

goat (1)

Isotype

IgG (22)

IgG1 (2)

IgG1,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (40)

Clone

1691CT516.3.3 (1)

OTI2D9 (2)

Format

APC (2)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (6)

Carrier-free (1)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Unconjugated (15)

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Epitope

aa166-348 (8)

aa453-647 (8)

aa597-625 (7)

aa551-600 (4)

aa580-629 (4)

aa175-438 (2)

aa1-44 (1)

aa2-14 (1)

aa833-883 (1)

pThr790 (1)

Publications

No (49)

Tag

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

ECT2 Antibody (aa175-438, clone OTI2D9) LS-C340261

Antibody:

ECT2 Mouse anti-Human Monoclonal (aa175-438) (OTI2D9) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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ECT2 Antibody (aa175-438, clone OTI2D9, Carrier-free) LS-C791233

Antibody:

ECT2 Mouse anti-Human Monoclonal (aa175-438) (Carrier-free) (OTI2D9) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

ECT2 Antibody (aa597-625) LS-C167617

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

ECT2 Antibody (phospho-Thr790) LS-C19111

Antibody:

ECT2 Rabbit anti-Human Polyclonal (pThr790) Antibody

Reactivity:

Chicken, Zebrafish, Rat, Mouse, Dog, Human, Chimpanzee

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$567

Select

Human ECT2 Protein (Recombinant His, N-Terminal) (aa453-647) - LS-G14924

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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ECT2 Antibody LS-C673888

Antibody:

ECT2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

ECT2 Antibody (aa597-625) LS-C321012

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

ECT2 Antibody (aa597-625, Biotin) LS-C234849

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

ECT2 Antibody (aa597-625, FITC) LS-C234851

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

ECT2 Antibody (aa597-625, Azide-free, HRP) LS-C249888

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

ECT2 Antibody (aa597-625, APC) LS-C234848

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

ECT2 Antibody (aa597-625, PE) LS-C234852

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa597-625) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

ECT2 Antibody LS-C832683

Antibody:

ECT2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

ECT2 Antibody (clone 1691CT516.3.3) LS-C757923

Antibody:

ECT2 Mouse anti-Human Monoclonal (1691CT516.3.3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

ECT2 Antibody (aa1-44) LS-C311440

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa1-44) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$450

Select

ECT2 Antibody (aa551-600) LS-C81717

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa551-600) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

ECT2 Antibody (aa551-600, HRP) LS-C455976

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa551-600) (HRP) Antibody

Reactivity:

Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

ECT2 Antibody (aa551-600, Biotin) LS-C455974

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa551-600) (Biotin) Antibody

Reactivity:

Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

ECT2 Antibody (aa551-600, FITC) LS-C455975

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa551-600) (FITC) Antibody

Reactivity:

Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

ECT2 Antibody (aa580-629) LS-C81718

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa580-629) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

ECT2 Antibody (aa580-629, HRP) LS-C455979

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa580-629) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

ECT2 Antibody (aa833-883) LS-C289095

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa833-883) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ECT2 Antibody (aa166-348) LS-C294137

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa166-348) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

ECT2 Antibody (aa453-647) LS-C294138

Antibody:

ECT2 Rabbit anti-Human Polyclonal (aa453-647) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

ECT2 Antibody (aa2-14) LS-C54498

Antibody:

ECT2 Goat anti-Human Polyclonal (aa2-14) Antibody

Reactivity:

Human, Monkey

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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