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ECT2

epithelial cell transforming sequence 2 oncogene

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Gene Name: epithelial cell transforming sequence 2 oncogene
Synonyms: ECT2, ARHGEF31, Protein ECT2
Target Sequences: NM_018098 NP_060568.3 Q9H8V3

☰ Filters
Antibodies (43)
Proteins (6)
Over-Expression Lysate (2)
Primary (43)
Recombinant (4)
ECT2 (49)
Human (43)
Mouse (9)
Rat (7)
Bat (3)
Bovine (3)
Chicken (1)
Chimpanzee (7)
Dog (7)
Gibbon (6)
Guinea pig (6)
Horse (3)
Monkey (7)
Rabbit (6)
Zebrafish (4)
IHC (12)
IHC-P (4)
WB (36)
ELISA (10)
IP (1)
Peptide-ELISA (1)
rabbit (39)
mouse (3)
goat (1)
IgG (22)
IgG1 (2)
IgG1,k (1)
monoclonal mc (3)
polyclonal pc (40)
1691CT516.3.3 (1)
OTI2D9 (2)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (6)
Carrier-free (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (15)
aa166-348 (8)
aa453-647 (8)
aa597-625 (7)
aa551-600 (4)
aa580-629 (4)
aa175-438 (2)
aa1-44 (1)
aa2-14 (1)
aa833-883 (1)
pThr790 (1)
No (49)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
ECT2 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ECT2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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ECT2 Mouse anti-Human Monoclonal (aa175-438) (OTI2D9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
ECT2 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ECT2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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ECT2 Mouse anti-Human Monoclonal (aa175-438) (Carrier-free) (OTI2D9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ECT2 Antibody - ECT2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung squamous carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ECT2 Antibody - Anti-ECT2 pT790 Antibody - Western Blot. Western blot of affinity purified anti-ECT2 pT790 antibody shows detection of endogenous phosphorylated ECT2 (arrowhead) present in cell lysates from interphase (lane 1) and mitotic (lane 2) HeLa cells. Despite specific staining of interphase cells, this reagent is believed to be phospho specific based on ELISA results using both phosphorylated and non-phosphorylated immunizing peptide. After SDS-PAGE and transfer, the membrane was probed with the primary antibody diluted to 1:1000. Personal Communication, Toru Miki, CCR-NCI, Bethesda, MD.
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ECT2 Rabbit anti-Human Polyclonal (pThr790) Antibody
Chicken, Zebrafish, Rat, Mouse, Dog, Human, Chimpanzee
ELISA, IP, WB
Unconjugated
100 µg/$567
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E. coli
His, N-Terminal
23.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
ECT2 Antibody - Immunohistochemistry image at a dilution of 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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ECT2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
ECT2 Rabbit anti-Human Polyclonal (aa597-625) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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ECT2 Rabbit anti-Human Polyclonal (aa597-625) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
ECT2 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer tissue  using ECT2 Polyclonal Antibody at dilution of 1:35(×200)
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ECT2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ECT2 Antibody - Anti-ECT2 Antibody at 1:1000 dilution + 293T/17 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 104 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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ECT2 Mouse anti-Human Monoclonal (1691CT516.3.3) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
ECT2 Antibody - Anti-ECT2 antibody [N1], N-term used in IHC (Formalin-fixed paraffin-embedded sections).
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ECT2 Rabbit anti-Human Polyclonal (aa1-44) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$450
ECT2 Antibody - Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa551-600) Antibody
Human
WB
Unconjugated
100 µl/$424
ECT2 Antibody - Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa551-600) (HRP) Antibody
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon
WB
HRP Conjugated
100 µl/$469
ECT2 Antibody - Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa551-600) (Biotin) Antibody
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
ECT2 Antibody - Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa551-600) (FITC) Antibody
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Chimpanzee, Gibbon
WB
FITC Conjugated
100 µl/$469
ECT2 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa580-629) Antibody
Human
WB
Unconjugated
100 µl/$424
ECT2 Antibody - HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa580-629) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
ECT2 Antibody - Detection of Human ECT2 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa and 293T (T; 50 ug) cells. Antibody: Affinity purified rabbit anti-ECT2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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ECT2 Rabbit anti-Human Polyclonal (aa833-883) Antibody
Mouse, Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
ECT2 Antibody - Western blot of recombinant ECT2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa453-647) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
ECT2 Antibody - Western blot of recombinant ECT2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ECT2 Rabbit anti-Human Polyclonal (aa166-348) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Select
ECT2 Goat anti-Human Polyclonal (aa2-14) Antibody
Human, Monkey
Peptide-ELISA
Unconjugated
100 µg/$503
Viewing 1-25 of 49 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).