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This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants.
Gene Name: | endothelin converting enzyme 2 |
Family/Subfamily: | Protease , Metallopeptidase M13 |
Synonyms: | ECE2, ECE-2, Endothelin-converting enzyme 2, KIAA0604, Endothelin converting enzyme 2 |
Target Sequences: | NM_014693 NP_055508.3 O60344 |
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