E6AP / UBE3A

ubiquitin protein ligase E3A

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

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Products

ELISA Kits (7)

Type

Sandwich (6)

Sandwich CLIA (1)

Target

E6AP / UBE3A (7)

Reactivity

Human (5)

Mouse (1)

Monkey (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (5)

Publications

No (7)

Sample Type

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (2)

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F4413

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F20296

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human E6AP / UBE3A (CLIA) ELISA Kit - LS-F29813

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F35509

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F12892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Monkey E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F48951

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human E6AP / UBE3A (Sandwich ELISA) ELISA Kit - LS-F22063

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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