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E2F6
E2F transcription factor 6
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
| Gene Name: | E2F transcription factor 6 |
| Synonyms: | E2F6, E2F transcription factor 6, E2F-6, Transcription factor E2F6 |
| Target Sequences: | AF032131 AAC53521.1 O54917 |
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