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Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner.
Gene Name: | E2F transcription factor 3 |
Synonyms: | E2F3, E2F transcription factor 3, KIAA0075, Transcription factor E2F3, E2F-3 |
Target Sequences: | NM_001949 NP_001940.1 O00716 |
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