DYRK / DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

DYRK / DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

DYRK / DYRK1A (6)

Publications

No (6)

Tag

DDK,C-terminus (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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DYRK / DYRK1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107674

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.4 kDa

Price:

100 µg/$710

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Human DYRK / DYRK1A Protein (Recombinant DDK,C-terminus) - LS-G142339

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

85.6 kDa

Price:

20 µg/$677

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Human DYRK / DYRK1A Protein (Recombinant His) - LS-G2937

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human DYRK / DYRK1A Protein (Recombinant His-T7) (aa16-300) - LS-G25967

Source:

E. coli

Tag:

His-T7

Molecular Weight:

37.3 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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Human DYRK / DYRK1A Protein (Recombinant GST, N-terminus) (aa674-763) - LS-G58390

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DYRK / DYRK1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78781

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.4 kDa

Price:

20 µg/$215

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