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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Gene Name: | dynein, cytoplasmic 1, intermediate chain 1 |
Synonyms: | DYNC1I1, DNCI1, DNCIC1, DH IC-1 |
Target Sequences: | NM_004411 NP_004402.1 O14576 |
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