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DUOX is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Gene Name: | dual oxidase 1 |
Synonyms: | DUOX1, DUOX, Flavoprotein NADPH oxidase, Long NOX 1, NOXEF1, Large NOX 1, Thyroid oxidase 1, NADPH thyroid oxidase 1, THOX1, Dual oxidase 1, LNOX1 |
Target Sequences: | NM_017434 NP_059130.2 Q9NRD9 |
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