DTNBP1 / Dysbindin

dystrobrevin binding protein 1

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

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Products

Proteins (13)

Type

Over-Expression Lysate (4)

Recombinant (9)

Target

DTNBP1 / Dysbindin (13)

Publications

No (13)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (6)

Species

Human (9)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human DTNBP1 / Dysbindin Protein (Recombinant His, N-Terminal) (Gln100-Ser351) - LS-G132685

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

31.9kDa

Price:

10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298

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Human DTNBP1 / Dysbindin Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G63341

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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DTNBP1 / Dysbindin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103977

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.7 kDa

Price:

100 µg/$494

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Human DTNBP1 / Dysbindin Protein (Recombinant His, N-Terminal) - LS-G144982

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

39.3 kDa

Price:

50 µg/$419

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Human DTNBP1 / Dysbindin Protein (Recombinant GST) (Full Length) - LS-G35651

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DTNBP1 / Dysbindin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68952

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$1,107

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Human DTNBP1 / Dysbindin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68954

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.2 kDa

Price:

20 µg/$1,107

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Human DTNBP1 / Dysbindin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83489

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$150

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Human DTNBP1 / Dysbindin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83490

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.7 kDa

Price:

20 µg/$150

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DTNBP1 / Dysbindin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102051

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

100 µg/$494

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Human DTNBP1 / Dysbindin Protein (Recombinant His) - LS-G498

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Mouse DTNBP1 / Dysbindin Protein (Recombinant) (Gln179-Glu319) - LS-G133692

Source:

E. coli

Tag:

None

Molecular Weight:

19.5kDa

Price:

10 µg/$262; 50 µg/$339; 200 µg/$642; 100 µg/$512; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Rat DTNBP1 / Dysbindin Protein (Recombinant) (Asp110-Leu305) - LS-G133728

Source:

E. coli

Tag:

None

Molecular Weight:

26.0kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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