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DSG1 / Desmoglein 1

desmoglein 1

DSG1 / Desmoglein 1 is a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.

Gene Name: desmoglein 1
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: DSG1, CDHF4, Cadherin family member 4, Desmoglein 1, DG1, Desmoglein-1, Desmosomal glycoprotein 1, SPPK1, DGI, DSG, Pemphigus foliaceus antigen, PPKS1
Target Sequences: NM_001942 NP_001933.2 Q02413

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Products
Proteins (3)
Recombinant (3)
DSG1 / Desmoglein 1 (3)
No (3)
10His, N-terminus + Myc, C-terminus (1)
GST (1)
His-GST (1)
Human (3)
E. coli (2)
Wheat Germ Extract (1)
Purified (2)
DSG1 / Desmoglein 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
100 µg/$1,128; 20 µg/$721
DSG1 / Desmoglein 1 Protein - 12.5% SDS-PAGE of human DSG1 stained with Coomassie Blue
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Wheat Germ Extract
GST
142.34 kDa
2 µg/$439
DSG1 / Desmoglein 1 Protein - Recombinant Desmoglein 1 By SDS-PAGE
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E. coli
His-GST
58.6 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).