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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DPYD / DPD

dihydropyrimidine dehydrogenase

Dihydropyrimidine dehydrogenase (DPYD) is a pyrimidine catabolic enzyme and the initial and rate-limiting step in the pathway of uracil and thymidine catabolism and also in the pathway leading to the formation of beta-alanine. The DPYD gene is a large gene of approximately 150 kb consisting of 23 exons encoding a protein of approximately 111-kD. Genetic deficiency of DPYD enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-flourouracil chemotherapy.

Gene Name: dihydropyrimidine dehydrogenase
Synonyms: DPYD, Dihydrouracil dehydrogenase, DPD, Dihydrothymine dehydrogenase, DHP, DHPDHASE
Target Sequences: NM_000110 NP_000101.2 Q12882

Filtered by: None
Type
Over-Expression Lysate (3)
Recombinant (5)
Target
DPYD / DPD (8)
Tag
GST (1)
GST,N-terminus (1)
His + S (1)
His + T7 (1)
Myc + DDK (4)
Species
Human (5)
Mouse (1)
Source
293T Cells (1)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purification
Purified (1)
Publications
No (8)
Showing 1-8 of 8 results

Human DPYD / DPD Protein (Recombinant GST,N-terminus) (aa1-110) - LS-G58363
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human DPYD / DPD Protein (Recombinant Myc + DDK) (Full Length) - LS-G65415
HEK 293 Cells
Myc + DDK
111.2 kDa
20µg  $950.00
Purified recombinant protein DPYD was analyzed by SDS-PAGE gel and Coomassie Blue Staining

DPYD / DPD Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G123386
HEK 293 Cells
Myc + DDK
111.2 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

DPYD / DPD Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G127898
HEK 293 Cells
Myc + DDK
18.8 kDa
100µg  $345.00

Human DPYD / DPD Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G75525
293T Cells
Myc + DDK
111.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human DPYD / DPD Protein (Recombinant His + S) (aa781-1025) - LS-G24599
E. coli
His + S
30.6 kDa
10µg  $285.00; 50µg  $465.00; 100µg  $620.00; 200µg  $905.00; 1mg  $2,310.00; 500µg  $1,020.00
Recombinant  Dihydropyrimidine Dehydrogenase By SDS-PAGE

Mouse DPYD / DPD Protein (Recombinant His + T7) (aa169-422) - LS-G24600
E. coli
His + T7
31.6 kDa
10µg  $285.00; 50µg  $465.00; 100µg  $620.00; 200µg  $905.00; 1mg  $2,310.00; 500µg  $1,020.00
Recombinant Dihydropyrimidine Dehydrogenase By SDS-PAGE

Human DPYD / DPD Protein (Recombinant GST) (Full Length) - LS-G28246
Wheat Germ Extract
GST
44.66 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human DPYD stained with Coomassie Blue
Showing 1-8 of 8 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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