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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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DPP4 / CD26
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:4482-7. (WB; Rat)[Full Text Article]
Related Antibodies: LS-C122983.
Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines. Amatya VJ, Takeshima Y, Kushitani K, Yamada T, Morimoto C, Inai K. Oncology reports. 2011 26:1369-75. (IHC-P; Human)[Full Text Article]
Related Antibodies: LS-A8060.