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DPP / DSPP is two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.
Gene Name: | Dentin Sialophosphoprotein |
Synonyms: | DSPP, Dentin phosphoprotein, DFNA39, DPP, Dentin phosphophoryn, Dentin sialoprotein, DGI1, DMP3, DTDP2, Dentin phosphoryn, Dentin sialophosphoprotein |
Target Sequences: | NM_014208 NP_055023.2 Q9NZW4 |
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