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Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). May have a regulatory role, promoting dissociation of diphthine synthase DPH5 from elongation factor 2.
Gene Name: | diphthamide biosynthesis 7 |
Synonyms: | DPH7, C9orf112, RP11-48C7.3, WD repeat domain 85, WDR85, RRT2 |
Target Sequences: | NM_138778 NP_620133.1 Q9BTV6 |
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