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DOCK7

dedicator of cytokinesis 7

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.

Gene Name:	dedicator of cytokinesis 7
Synonyms:	DOCK7, Dedicator of cytokinesis 7, KIAA1771, ZIR2
Target Sequences:	AB051558 BAB21862.1 Q96N67

DOCK7 Protein - 12.5% SDS-PAGE of human DOCK7 stained with Coomassie Blue

Human DOCK7 Protein (Recombinant GST) (Full Length) - LS-G35918

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.2 kDa

Price:

10 µg/$479; 25 µg/$670

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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