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DOCK180 / DOCK1

dedicator of cytokinesis 1

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

Gene Name:	dedicator of cytokinesis 1
Synonyms:	DOCK1, Dedicator of cytokinesis 1, Dedicator of cyto-kinesis 1, DOwnstream of CrK, Ced5, DOCK180
Target Sequences:	NM_001380 NP_001371.1 Q14185

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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