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DNTT / TdT
DNA nucleotidylexotransferase
DNTT / TdT is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
| Gene Name: | DNA nucleotidylexotransferase |
| Synonyms: | DNTT, DNA nucleotidylexotransferase, TDT, Terminal addition enzyme, Terminal transferase |
| Target Sequences: | NM_004088 NP_004079.3 P04053 |
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