DNM1L / DRP1

dynamin 1-like

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

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ELISA Kits (6)

Type

Competitive EIA (1)

Custom (1)

Sandwich (4)

Target

DNM1L / DRP1 (6)

Reactivity

Human (2)

Mouse (1)

Rat (2)

Bovine (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (4)

Publications

No (6)

Sample Type

Cell Lysates (2)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Human DNM1L / DRP1 (Sandwich ELISA) ELISA Kit - LS-F74159

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Mouse DNM1L / DRP1 (Sandwich ELISA) ELISA Kit - LS-F67061

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human DNM1L / DRP1 (Competitive EIA) ELISA Kit - LS-F66488

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine DNM1L / DRP1 (Custom) ELISA Kit - LS-F65699

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Rat DNM1L / DRP1 (Sandwich ELISA) ELISA Kit - LS-F74154

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

Select

Rat DNM1L / DRP1 (Sandwich ELISA) ELISA Kit - LS-F66961

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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