DMTN / Dematin

dematin actin binding protein

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.

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Products

Proteins (13)

Type

Over-Expression Lysate (8)

Recombinant (5)

Target

DMTN / Dematin (13)

Publications

No (13)

Tag

DDK,C-terminus (1)

GST (1)

Myc-DDK (Flag) (11)

Species

Human (9)

Source

293T Cells (4)

HEK 293 Cells (7)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124336

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

100 µg/$494

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DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124338

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

100 µg/$494

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DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124340

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

100 µg/$494

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DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118265

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

100 µg/$494

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Human DMTN / Dematin Protein (Recombinant DDK,C-terminus) - LS-G142487

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

45.3 kDa

Price:

20 µg/$677

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Human DMTN / Dematin Protein (Recombinant GST) (Full Length) - LS-G28361

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DMTN / Dematin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69724

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$1,107

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Human DMTN / Dematin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69726

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$1,107

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Human DMTN / Dematin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69725

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$1,107

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Human DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85415

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$150

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Human DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85416

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$150

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Human DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85417

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

20 µg/$150

Select

Human DMTN / Dematin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85418

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$150

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