DMPK / DM

dystrophia myotonica-protein kinase

Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

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Products

Proteins (11)

Type

Over-Expression Lysate (6)

Recombinant (5)

Target

DMPK / DM (11)

Publications

No (11)

Tag

GST (1)

His-T7 (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (8)

Species

Human (7)

Rat (1)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (5)

Wheat Germ Extract (1)

Purification

Purified (1)

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DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116661

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.2 kDa

Price:

100 µg/$494

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DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119753

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.8 kDa

Price:

100 µg/$710

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DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119754

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.4 kDa

Price:

100 µg/$710

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Human DMPK / DM Protein (Recombinant His-T7) (aa1-201) - LS-G25025

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.1 kDa

Price:

10 µg/$269; 50 µg/$370; 100 µg/$590; 200 µg/$737; 1 mg/$1,779; 500 µg/$1,345; 5 mg/$2,736; 2 mg/$1,959

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Human DMPK / DM Protein (Recombinant GST) (Full Length) - LS-G28221

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

94.93 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DMPK / DM Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66359

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.2 kDa

Price:

20 µg/$1,107

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Human DMPK / DM Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66360

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.4 kDa

Price:

20 µg/$1,107

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Human DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77545

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.8 kDa

Price:

20 µg/$215

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Human DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77546

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.4 kDa

Price:

20 µg/$215

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Human DMPK / DM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77547

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.2 kDa

Price:

20 µg/$150

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Rat DMPK / DM Protein (Recombinant His-T7, N-terminus) (Met1-Val152) - LS-G133559

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

21.5kDa

Price:

10 µg/$274; 50 µg/$400; 200 µg/$797; 100 µg/$637; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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