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DLAT / PDC-E2

dihydrolipoamide S-acetyltransferase

DLAT / PDC-E2 is component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene Name: dihydrolipoamide S-acetyltransferase
Synonyms: DLAT, DLTA, PDC-E2, PBC, PDCE2
Target Sequences: NM_001931 NP_001922.2 P10515

☰ Filters
Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
DLAT / PDC-E2 (9)
No (9)
6His, N-terminus (3)
GST (1)
His, N-Terminal (2)
Myc-DDK (Flag) (3)
Human (5)
Mouse (3)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (5)
DLAT / PDC-E2 Protein - Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Recombinant Mouse Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial(Dlat) could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Dlat.
Select
E. coli
6His, N-terminus
62.8 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
DLAT / PDC-E2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
DLAT / PDC-E2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DLAT / PDC-E2 Protein
Select
E. coli
His, N-Terminal
29.0 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
DLAT / PDC-E2 Protein
Select
E. coli
His, N-Terminal
28.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
DLAT / PDC-E2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
69 kDa
100 µg/$494
DLAT / PDC-E2 Protein - 12.5% SDS-PAGE of human DLAT stained with Coomassie Blue
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Wheat Germ Extract
GST
95.4 kDa
2 µg/$439
DLAT / PDC-E2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
69 kDa
20 µg/$150
DLAT / PDC-E2 Protein - Purified recombinant protein DLAT was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.6 kDa
20 µg/$1,107
Viewing 1-9 of 9 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).